Why the enzyme defect matters (in everyday language)

Think of the tyrosine breakdown pathway as a factory line. If the last machine (FAH) breaks down, intermediate products pile up and start leaking into other systems. One of those leaked products, succinylacetone, is particularly harmful to liver cells and kidney tubules.

https://notacares.stck.me/post..../1375949/How-Tyrosin

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